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Emixustat hydrochloride

CAS No. 1141934-97-5

Emixustat hydrochloride( ACU-4429 hydrochloride )

Catalog No. M10504 CAS No. 1141934-97-5

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Emixustat hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
  • Description
    Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM; reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).Other Indication Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ACU-4429 hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    1141934-97-5
  • Formula Weight
    299.8362
  • Molecular Formula
    C16H26ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 44 mg/mL
  • SMILES
    C1CCC(CC1)COC2=CC=CC(=C2)C(CCN)O.Cl
  • Chemical Name
    Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, hydrochloride (1:1), (αR)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15. 2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940. 3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.
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