Emixustat hydrochloride

CAS No. 1141934-97-5

Emixustat hydrochloride ( ACU-4429 hydrochloride )

Catalog No. M10504 CAS No. 1141934-97-5

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 88 Get Quote
5MG 161 Get Quote
10MG 257 Get Quote
25MG 430 Get Quote
50MG 618 Get Quote
100MG 898 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Emixustat hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
  • Description
    Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM; reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).Other Indication Phase 3 Clinical
  • Synonyms
    ACU-4429 hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    1141934-97-5
  • Formula Weight
    299.84
  • Molecular Formula
    C16H26ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 44 mg/mL
  • SMILES
    C1CCC(CC1)COC2=CC=CC(=C2)C(CCN)O.Cl
  • Chemical Name
    Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, hydrochloride (1:1), (αR)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15.
2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.
3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.
molnova catalog
related products
  • Levothyroxine sodium

    Levothyroxine, the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR.

  • Ophiopogonin B

    Ophiopogonin B has antitumor activity and is a prospective inhibitor of PI3K/Akt.

  • Magnolignan C

    Magnolignan C is a natural product from Magnolia officinalis.